Stout S A, Derendorf H
Drug Intell Clin Pharm. 1987 Apr;21(4):322-9. doi: 10.1177/106002808702100402.
Local administration of antibiotics for the treatment of respiratory infections has the potential advantage of reduced systemic toxicity and increased drug concentration at the site of infection. This article reviews the basic principles of pulmonary drug delivery using aerosols and the clinical efficacy of local antibiotic therapy of respiratory infections. Clinical studies have been conducted with locally administered aminoglycosides, penicillins, cephalosporins, and polypeptides. The results of these investigations and the pharmacokinetic aspects of pulmonary antibiotic delivery are summarized.
局部应用抗生素治疗呼吸道感染具有降低全身毒性以及提高感染部位药物浓度的潜在优势。本文综述了使用气雾剂进行肺部给药的基本原理以及呼吸道感染局部抗生素治疗的临床疗效。已对局部应用的氨基糖苷类、青霉素类、头孢菌素类和多肽类药物进行了临床研究。总结了这些研究的结果以及肺部抗生素给药的药代动力学方面。
