Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Int J Pharm. 2022 Jun 10;621:121797. doi: 10.1016/j.ijpharm.2022.121797. Epub 2022 May 4.
While Pickering emulsions have been known since 1906, where oil droplets are dispersed in aqueous media owing to nanoparticles decorating each oil droplet, no solid lipid microparticles decorated with nanoparticles have been described. These Solid-Pickering microparticles are surfactant-free micro-scale spherical active agent carriers composed of beeswax as a natural solid lipid with chitosan and starch nanoparticles embedded in the surface. Microparticles of this type were made by dispersing molten lipid in hot aqueous media containing dispersed nanoparticles to create microdroplets. Once the droplets are cooled below the melting point of the lipid, the microparticles of spherical form are obtained. The novel system allows encapsulation of active agents within a solid lipid core which is slowly released over time. It has been demonstrated through encapsulation of Ibuprofen and Lidocaine as a model poorly water-soluble drugs and an extended-release profile (for at least a week) was achieved. These Solid Pickering microparticles can be used in food, medicine, agriculture, and personal care products.
虽然 Pickering 乳液自 1906 年以来就为人所知，其中的油滴由于纳米粒子修饰每个油滴而分散在水介质中，但尚未有描述纳米粒子修饰的固体脂质微球。这些固体 Pickering 微球是无表面活性剂的微尺度球形活性剂载体，由蜂蜡作为天然固体脂质组成，壳聚糖和淀粉纳米粒子嵌入在表面。这种类型的微球是通过将熔融脂质分散在含有分散纳米粒子的热水性介质中以形成微滴来制备的。一旦微滴冷却到脂质的熔点以下，就得到了球形的微球。该新型体系允许将活性剂封装在固体脂质核内，活性剂会随着时间的推移缓慢释放。通过封装布洛芬和利多卡因作为模型难溶于水的药物，已经证明可以实现延长释放（至少一周）。这些固体 Pickering 微球可用于食品、医药、农业和个人护理产品。
