Yang Liyu, Xu Zhijie, Liu Jie, Chang Xiyue, Ren Zhaozhou, Xiao Wan'an
Department of Orthopedics, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning 110004, China.
Department of Epidemiology, School of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang, Liaoning 110013, China.
Burns Trauma. 2025 May 28;13:tkaf019. doi: 10.1093/burnst/tkaf019. eCollection 2025.
To preserve functionality, bone is an active tissue that can constantly reconstruct itself through modeling and remodeling. It plays critical roles in the body, including maintaining mineral homeostasis, serving as the adult human body's core site of hematopoiesis, and supporting the structures of the body's soft tissues. It possesses the natural regeneration capacity, but large and complex lesions often require surgical intervention. Multiple omics integrate proteomics, metabolomics, genomics, and transcriptomics to provide a comprehensive understanding of biological processes like bone tissue injury and healing in bone tissue regeneration and engineering. Recently, bone tissue engineering and regenerative medicines have offered promising tools for bone regeneration using a multi-omics approach. Thus, this article will highlight the role of multiple omics in understanding bone tissue injury and healing. It will discuss the role of bone tissue engineering in developing bone substitutes that can replace translational medicine. Lastly, new developments in bone tissue engineering and regenerative medicine, along with multi-omics approaches, offer promising tools for bone regeneration.
为保持功能，骨骼是一种活跃组织，能够通过塑形和重塑不断自我重建。它在人体中发挥着关键作用，包括维持矿物质稳态、作为成人体内造血的核心部位以及支撑身体软组织的结构。骨骼具有自然再生能力，但大的复杂损伤通常需要手术干预。多组学整合了蛋白质组学、代谢组学、基因组学和转录组学，以全面了解骨组织再生与工程中骨组织损伤和愈合等生物学过程。最近，骨组织工程和再生医学利用多组学方法为骨再生提供了有前景的工具。因此，本文将重点介绍多组学在理解骨组织损伤和愈合中的作用。将讨论骨组织工程在开发可替代转化医学的骨替代物方面的作用。最后，骨组织工程和再生医学的新进展以及多组学方法为骨再生提供了有前景的工具。
