从遗传学角度看细胞分裂。
Cell division from a genetic perspective.
作者信息
Hartwell L H
出版信息
J Cell Biol. 1978 Jun;77(3):627-37. doi: 10.1083/jcb.77.3.627.
Abstract
A novel view of the eukaryotic cell cycle is taking form as genetic strategies borrowed from investigations of microbial gene regulation and bacteriophage morphogenesis are being applied to the process of cell division. It is a genetic construct in which mutational lesions identify the primary events, thermolabile gene products reveal temporal order, mutant phenotypes yield pathways of causality, and regulatory events are localized within sequences of gene controlled steps.
摘要
一种关于真核细胞周期的全新观点正在形成，因为从微生物基因调控和噬菌体形态发生研究中借鉴的遗传策略正被应用于细胞分裂过程。这是一种遗传架构，其中突变损伤可识别主要事件，温度敏感型基因产物揭示时间顺序，突变表型产生因果关系路径，并且调控事件定位在基因控制步骤的序列之中。
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