氟化物牙科树脂系统的制备及其对变异链球菌的抗黏附性能。
Preparation of a fluorinated dental resin system and its anti-adhesive properties against S. mutans.
机构信息
Nordic Institute of Dental Materials (NIOM), Oslo, Norway; College of Materials Science and Engineering, South China University of Technology, China; Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Finland.
Nordic Institute of Dental Materials (NIOM), Oslo, Norway.
出版信息
Dent Mater. 2023 Apr;39(4):402-409. doi: 10.1016/j.dental.2023.03.009. Epub 2023 Mar 7.
OBJECTIVES
The purpose of this study was to characterize physicochemical properties and investigate anti-bacterial adhesion effect of dental resins containing fluorinated monomers.
METHOD
Fluorinated dimethacrylate FDMA was mixed with commonly used reactive diluent triethylene- glycol dimethacrylate (TEGDMA) and fluorinated diluent 1 H,1 H-heptafluorobutyl methacrylate (FBMA) separately at a mass ratio of 60 wt./40 wt. to prepare fluorinated resin systems. Double bond conversion (DC), flexural strength (FS) and modulus (FM), water sorption (WS) and solubility (SL), contact angle and surface free energy, surface element concentration, and anti-adhesion effect against Streptococcus mutans (S. mutans) were investigated according to standard or referenced methods. 2,2-bis[4-(2-hydroxy-3-methacryloy-loxypropyl)-phenyl]propane (Bis-GMA)/TEGDMA (60/40, wt./wt.) was used as control.
RESULTS
Both fluorinated resin systems had higher DC than Bis-GMA based resin (p < 0.05); compared with Bis-GMA based resin (FS, FDMA/TEGDMA resin system had higher FS (p < 0.05) and comparable FM (p > 0.05), while FDMA/FBMA resins system had lower FS and FM (p < 0.05). Both fluorinated resin systems had lower WS and SL than Bis-GMA based resin (p < 0.05), and FDMA/TEGDMA resin system had the lowest WS (p < 0.05) in all experimental resin systems. Only FDMA/FBMA resin system showed lower surface free energy than Bis-GMA based resin (p < 0.05). When the surface was smooth, FDMA/FBMA resin system had lower amount of adherent S. mutans than Bis-GMA based resin (p < 0.05), while after the surface became roughness, FDMA/FBMA resin system had comparable amount of adherent S. mutans as Bis-GMA based resin (p > 0.05).
SIGNIFICANCE
Resin system prepared exclusively with fluorinated methacrylate monomers reduced the S. mutans adhesion due to their increased hydrophobicity and decreased surface energy., while flexural properties of it should be improved.
目的
本研究旨在表征含氟单体的牙科树脂的物理化学性质，并研究其抗细菌黏附效果。
方法
将氟化二甲基丙烯酸酯 FDMA 分别与常用的反应性稀释剂三乙二醇二甲基丙烯酸酯（TEGDMA）和氟化稀释剂 1H，1H-七氟丁基甲基丙烯酸酯（FBMA）以 60wt./40wt. 的质量比混合，制备氟化树脂体系。根据标准或参考方法，研究双健转化率（DC）、弯曲强度（FS）和模量（FM）、吸水率（WS）和溶解度（SL）、接触角和表面自由能、表面元素浓度以及对变形链球菌（S. mutans）的抗黏附效果。以 2,2-双[4-（2-羟基-3-丙烯酰氧基丙基）-苯基]丙烷（Bis-GMA）/TEGDMA（60/40，wt./wt.）为对照。
结果
两种氟化树脂体系的 DC 均高于 Bis-GMA 基树脂（p<0.05）；与 Bis-GMA 基树脂相比，FDMA/TEGDMA 树脂体系具有更高的 FS（p<0.05）和可比的 FM（p>0.05），而 FDMA/FBMA 树脂体系的 FS 和 FM 较低（p<0.05）。两种氟化树脂体系的 WS 和 SL 均低于 Bis-GMA 基树脂（p<0.05），所有实验树脂体系中 FDMA/TEGDMA 树脂体系的 WS 最低（p<0.05）。只有 FDMA/FBMA 树脂体系的表面自由能低于 Bis-GMA 基树脂（p<0.05）。当表面光滑时，FDMA/FBMA 树脂体系的黏附变形链球菌数量低于 Bis-GMA 基树脂（p<0.05），而当表面变得粗糙时，FDMA/FBMA 树脂体系的黏附变形链球菌数量与 Bis-GMA 基树脂相当（p>0.05）。
意义
仅由含氟甲基丙烯酸酯单体制备的树脂体系由于其疏水性增加和表面能降低，减少了变形链球菌的黏附，但应改善其弯曲性能。
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