血清脂质和短链脂肪酸对未经药物治疗的首发精神分裂症患者认知功能的影响。
The effect of serum lipids and short-chain fatty acids on cognitive functioning in drug-naïve, first episode schizophrenia patients.
机构信息
Department of Psychiatry, the First Affiliated Hospital/Zhengzhou University, Zhengzhou, China; Biological Psychiatry International Joint Laboratory of Henan/Zhengzhou University, Zhengzhou, China; Henan Psychiatric Transformation Research Key Laboratory/Zhengzhou University, Zhengzhou, China.
Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia.
出版信息
Psychiatry Res. 2022 Jul;313:114582. doi: 10.1016/j.psychres.2022.114582. Epub 2022 Apr 27.
OBJECTIVE
Many studies have reported the important role of serum levels of short-chain fatty acids (SCFAs) in lipid metabolism and cognitive dysfunction. This study investigated the role of plasma lipids and SCFAs on cognitive functioning in drug- naïve first episode schizophrenia.
METHODS
This study recruited 44 schizophrenia inpatients and 35 healthy controls. Plasma lipid metabolism was characterized using standard enzymatic methods and an automated analyzer. Serum levels of SCFAs were measured by Gas chromatography mass spectrometry (GC-MS). Cognitive performance was evaluated by the MATRICS Consensus Cognitive Battery (MCCB).
RESULTS
The patient group showed significantly higher serum levels of total SCFAs, acetic acid, acetic acid/ propionic acid ratio, and poorer cognitive scores compared with the control group (p's < 0.05). Within the patient group, the lipid levels were positively associated with acetic acid/ propionic acid ratio (p's < 0.05). Furthermore, multiple regression analysis revealed that the interactions of LDL level × acetic acid/ propionic acid ratio was a significant predictor of the MCCB working memory, and processing speed subscale scores within the patient group.
CONCLUSIONS
Cognitive dysfunction and abnormal serum levels of SCFAs occur in the early phase of schizophrenia. Lipid metabolism and serum levels of SCFAs might be, both independently or interactively, associated with cognitive dysfunction in schizophrenia.
目的
许多研究报告了短链脂肪酸（SCFAs）在脂代谢和认知功能障碍中的重要作用。本研究探讨了初发未用药精神分裂症患者血浆脂质和 SCFA 对认知功能的作用。
方法
本研究招募了 44 名精神分裂症住院患者和 35 名健康对照者。采用标准酶法和自动分析仪对血浆脂质代谢进行了特征描述。采用气相色谱质谱联用（GC-MS）法测定血清 SCFA 水平。采用 MATRICS 共识认知电池（MCCB）评估认知功能。
结果
与对照组相比，患者组的总 SCFA、乙酸、乙酸/丙酸比值显著升高，认知评分较差（p 值均<0.05）。在患者组中，血脂水平与乙酸/丙酸比值呈正相关（p 值均<0.05）。此外，多元回归分析显示，LDL 水平×乙酸/丙酸比值的交互作用是患者组 MCCB 工作记忆和处理速度子量表评分的显著预测因子。
结论
精神分裂症早期即出现认知功能障碍和 SCFA 血清水平异常。脂代谢和 SCFA 血清水平可能与精神分裂症的认知功能障碍有关，其作用可能是独立的，也可能是相互作用的。
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