基于纳米级金属有机框架的免疫增强型癌症免疫疗法。
Immunogenicity-boosted cancer immunotherapy based on nanoscale metal-organic frameworks.
机构信息
Department of Molecular Pathology, Application Center for Precision Medicine, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Department of Molecular Pathology, Application Center for Precision Medicine, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
出版信息
J Control Release. 2022 Jul;347:183-198. doi: 10.1016/j.jconrel.2022.05.003. Epub 2022 May 11.
Immunotherapy, including checkpoint blockade immunotherapy (CBI), has witnessed remarkable progress in cancer therapy. Nonetheless, significant obstacles to successful immunotherapy remain. Notably, tumour non-responsiveness to immunotherapy due to immunosuppressive tumour microenvironments (TMEs). To revitalize immunosuppressive TMEs various therapeutic strategies have been reported by researchers. Immunostimulatory adjuvant treatments (IAT) are the most widely investigated ones. Due to their biodegradability, compositional tenability, and inherent immune effectiveness, nanoscale metal-organic frameworks (nMOFs) with metal nodes and organic linkers can be used as versatile nanomaterials for IAT. This review summarizes the progress in nMOF-based tumour immunotherapy in promoting immunostimulatory TMEs. And in combination with other cancer immunotherapies to increase tumour immunogenicity and antitumor efficacy. Finally, the challenges of nMOFs in tumour immunotherapy are also discussed.
免疫疗法，包括检查点阻断免疫疗法（CBI），在癌症治疗方面取得了显著进展。然而，成功免疫疗法仍面临重大障碍。值得注意的是，由于免疫抑制性肿瘤微环境（TME），肿瘤对免疫疗法无反应。为了使免疫抑制性 TME 恢复活力，研究人员已经报道了各种治疗策略。免疫刺激佐剂治疗（IAT）是研究最广泛的一种。由于具有生物降解性、组成可调性和固有免疫有效性，具有金属节点和有机配体的纳米级金属-有机框架（nMOF）可用作用于 IAT 的多功能纳米材料。本综述总结了基于 nMOF 的肿瘤免疫疗法在促进免疫刺激 TME 方面的进展。并与其他癌症免疫疗法相结合，以提高肿瘤免疫原性和抗肿瘤疗效。最后，还讨论了 nMOF 在肿瘤免疫治疗中的挑战。
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