Department of Chemistry, University of California Irvine, Irvine, California 92697, USA.
Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697, USA.
Biomater Sci. 2022 Nov 22;10(23):6749-6754. doi: 10.1039/d2bm01240e.
Materials are needed to increase the stability and half-life of therapeutic proteins during delivery. These materials should be biocompatible and biodegradable. Here, we demonstrate that enzymes and immunoproteins can be encapsulated inside cyclodextrin based metal-organic frameworks using potassium as the metal node. The release profile can be controlled with the solubility of the cyclodextrin linker. The activity of the proteins after release is determined using catalytic and assays. The results show that cyclodextrin metal-organic framework-based protein biocomposites are a promising class of materials to deliver therapeutic proteins.
需要材料来提高治疗性蛋白质在递送上的稳定性和半衰期。这些材料应该是生物相容和可生物降解的。在这里，我们证明了酶和免疫蛋白可以被包封在基于环糊精的金属有机骨架内，使用钾作为金属节点。通过环糊精连接物的溶解度可以控制释放曲线。使用催化和免疫测定法来确定蛋白质释放后的活性。结果表明，基于环糊精金属有机骨架的蛋白质生物复合材料是一种很有前途的输送治疗性蛋白质的材料。
