Nieboer C, Kalsbeek G L
J Cutan Pathol. 1978 Apr;5(2):68-75. doi: 10.1111/j.1600-0560.1978.tb00940.x.
Direct immunofluorescence investigations were performed on skin biopsies from five patients with granuloma eosinophilicum faciale (GEF; facial granuloma). An extensive and brilliant granular picture was observed along the basement membrane (BM) of the epidermis and the hair follicles, in the walls of the vessels, in the cellular infiltrates and on the connective tissue fibers. These granules were positively stained by antisera directed against IgG, complement (C3/4) and, although less consistently, against IgA and IgM. IgE was found in one case along the BM, but anti- IgD was negative. Concomitantly heavy fibrillar deposits of fibrin were present in the walls of the vessels and in the cellular infiltrates, together with granular depositions along the BM. The analysis of the complement factors showed that C1q, C4, C3, C3c, C3d and C5 were present in the same pattern as C3/4. These results indicate that GEF can be considered as a chronic form of leukoclastic vasculitis mediated by an Arthus-like mechanism, maintained by an unidentified, persistent antigen or by locally produced Ig aggregates.
对5例面部嗜酸性肉芽肿（GEF；面部肉芽肿）患者的皮肤活检标本进行了直接免疫荧光检查。在表皮和毛囊的基底膜（BM）、血管壁、细胞浸润处以及结缔组织纤维上观察到广泛且明亮的颗粒状图像。这些颗粒被抗IgG、补体（C3/4）的抗血清呈阳性染色，虽然针对IgA和IgM的染色不太一致。在1例中，沿基底膜发现了IgE，但抗IgD为阴性。同时，血管壁和细胞浸润处存在大量纤维蛋白的纤维状沉积，以及沿基底膜的颗粒状沉积。补体因子分析表明，C1q、C4、C3、C3c、C3d和C5的存在模式与C3/4相同。这些结果表明，GEF可被视为一种由类似阿瑟斯反应机制介导的慢性白细胞破碎性血管炎，由未确定的持续性抗原或局部产生的Ig聚集体维持。
