SARS-CoV-2 变体 - 进化、刺突蛋白和疫苗。
SARS-CoV-2 variants - Evolution, spike protein, and vaccines.
机构信息
Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan.
Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, Taipei, Taiwan.
出版信息
Biomed J. 2022 Aug;45(4):573-579. doi: 10.1016/j.bj.2022.04.006. Epub 2022 May 6.
Abstract
Despite the rising natural and vaccines mediated immunity, several countries have experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. From Alpha to Omicron, the variants of concern (VOC) have evolved several spike protein mutations that may have an impact on virus characteristics, such as transmissibility and antigenicity. In this review, we describe the evolution of SARS-CoV-2, summarize current knowledge of epidemiological and clinical features of the variants, and discuss the response strategies in terms of vaccines to reduce the burden of COVID-19.
摘要
尽管自然和疫苗介导的免疫力不断增强，但由于严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）变异株的出现，一些国家的 2019 年冠状病毒病（COVID-19）再次出现。从 Alpha 到 Omicron，关切变异株（VOC）已经进化出几种刺突蛋白突变，这可能会影响病毒的特性，例如传染性和抗原性。在这篇综述中，我们描述了 SARS-CoV-2 的进化，总结了目前关于变异株的流行病学和临床特征的知识，并讨论了疫苗方面的应对策略，以减轻 COVID-19 的负担。
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