Vyas Maulik, Demehri Shadmehr
Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Trends Immunol. 2022 Jun;43(6):423-425. doi: 10.1016/j.it.2022.04.004. Epub 2022 May 5.
Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors. Together, recent studies highlight ECM as an active regulator of immunity in cancer.
细胞外基质（ECM）是实体癌的一个重要组成部分；然而，ECM对抗肿瘤免疫的影响一直难以捉摸。孙及其同事现在证明，盘状结构域受体1介导的胶原蛋白组装可以将T细胞排除在肿瘤之外。总之，最近的研究强调ECM是癌症免疫的一个活跃调节因子。
