Department of Biology, Queens College, City University of New York, Flushing, New York, United States.
PhD Program in Biology, The Graduate Center, City University of New York, New York, New York, United States.
Am J Physiol Cell Physiol. 2023 Nov 1;325(5):C1201-C1211. doi: 10.1152/ajpcell.00195.2023. Epub 2023 Sep 18.
Numerous conserved signaling pathways play critical roles in aging, including insulin/IGF-1, TGF-β, and Wnt pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidirectional relationship between these factors and providing a platform to address how regulation of and by the extracellular matrix can impact lifespan and organismal health during aging. These discoveries provide new opportunities for clinical advances and novel therapeutic strategies.
许多保守的信号通路在衰老过程中发挥着关键作用，包括胰岛素/IGF-1、TGF-β和 Wnt 通路。其中一些通路在细胞外基质的形成和维持中也起着重要作用。秀丽隐杆线虫一直是鉴定生物衰老保守机制的一个持久而富有成效的系统。最近在秀丽隐杆线虫中的研究强调了保守信号通路和细胞外基质之间的调节回路，揭示了这些因素之间的双向关系，并提供了一个平台来解决细胞外基质的调节如何影响衰老过程中的寿命和机体健康。这些发现为临床进展和新的治疗策略提供了新的机会。
