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Is it time for a moratorium on the use of benzalkonium chloride in eyedrops?

作者信息

D'andrea Luca, Montemagni Marina, Celenza Giuseppe, Iorio Roberto, Costagliola Ciro

机构信息

Department of Public Health, University of Naples Federico II, Naples, Italy.

Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.

出版信息

Br J Clin Pharmacol. 2022 Sep;88(9):3947-3949. doi: 10.1111/bcp.15359. Epub 2022 May 8.

DOI:10.1111/bcp.15359
PMID:35527385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9546014/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada0/9546014/976c3bfb757a/BCP-88-3947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada0/9546014/976c3bfb757a/BCP-88-3947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada0/9546014/976c3bfb757a/BCP-88-3947-g001.jpg

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Jpn J Ophthalmol. 2022 Mar;66(2):111-118. doi: 10.1007/s10384-021-00899-5. Epub 2022 Jan 10.
2
Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection.耐苯扎氯铵促进周期性消毒过程中快速产生耐药性。
Nat Commun. 2021 Nov 23;12(1):6792. doi: 10.1038/s41467-021-27019-8.
3
Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro.
苯扎氯铵保存的抗青光眼滴眼液及其对人结膜杯状细胞的体外作用。
Biomed Hub. 2021 Aug 13;6(2):69-75. doi: 10.1159/000517845. eCollection 2021 May-Aug.
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The treatment of glaucoma using topical preservative-free agents: an evaluation of safety and tolerability.局部无防腐剂制剂治疗青光眼：安全性和耐受性评价。
Expert Opin Drug Saf. 2021 Apr;20(4):453-466. doi: 10.1080/14740338.2021.1873947. Epub 2021 Jan 21.
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Benzalkonium Chloride Resistance in on the Ocular Surface of Glaucoma Patients Under Long-Term Administration of Eye Drops.眼局部长期滴用滴眼液的青光眼患者眼表耐苯扎氯铵铜绿假单胞菌。
Transl Vis Sci Technol. 2020 Jul 7;9(8):9. doi: 10.1167/tvst.9.8.9. eCollection 2020 Jul.
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