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病例报告:急性呼吸窘迫综合征和肺结节病患者合并 SARS-CoV-2 和 H1N1 流感感染。

Case Report: Co-infection with SARS-CoV-2 and influenza H1N1 in a patient with acute respiratory distress syndrome and a pulmonary sarcoidosis.

机构信息

Pole de Biopathologie , CS 86709, 45067 Orléans CEDEX , France, Centre Hospitalier Régional d'Orléans, 14 Avenu de l'Hôpital, Orléans, France.

UMR7355 INEM Immunologie et Neurogénétique Expérimentales & Moléculaires, CNRS & Université d'Orléans, 3B rue de la Ferollerie, Orléans CEDEX 2, 45071, France.

出版信息

F1000Res. 2020 Dec 18;9:1482. doi: 10.12688/f1000research.26924.2. eCollection 2020.

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been a global public health concern. We report coinfection of SARS-CoV-2 and 2009 H1N1 Influenza strain in a French patient with pneumonia leading to acute respiratory distress syndrome.  The patient also had a medical history of pulmonary sarcoidosis with a restrictive ventilatory syndrome and obesity, which would be a supplementary risk to develop a poor outcomes. This case highlights the possible coinfection of two severe SARS-CoV-2 and influenza H1N1 viruses in comorbid patient, which presents a higher risk to extend the care duration. The overlapping clinical features of the two respiratory syndromes is a challenge, and awareness is required to recommend an early differential diagnosis and it's necessary to adopt the vigilant preventive measures and therapeutic strategies to prevent a deleterious impacts in patients with comorbid factors.

摘要

2019 冠状病毒病(COVID-19)是由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染引起的,已成为全球公共卫生关注的焦点。我们报告了一例法国肺炎患者同时感染 SARS-CoV-2 和 2009 年 H1N1 流感株,导致急性呼吸窘迫综合征。该患者还患有肺结节病病史,伴有限制性通气综合征和肥胖,这将是导致不良结局的附加风险。本病例强调了两种严重的 SARS-CoV-2 和流感 H1N1 病毒在合并症患者中可能同时感染,这增加了延长治疗时间的风险。两种呼吸系统疾病的重叠临床特征是一个挑战,需要提高认识,建议进行早期鉴别诊断,有必要采取警惕性预防措施和治疗策略,以防止合并症患者产生有害影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2940/9065931/d8b16a6055d1/f1000research-9-129014-g0000.jpg

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