Department of Immunology, School of Medicine, Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Microb Pathog. 2021 Mar;152:104554. doi: 10.1016/j.micpath.2020.104554. Epub 2020 Nov 3.
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global public health emergency since December 2019, and so far, more than 980,000 people (until September 24, 2020) around the world have died. SARS-CoV-2 mimics the influenza virus regarding methods and modes of transmission, clinical features, related immune responses, and seasonal coincidence. Accordingly, co-infection by these viruses is imaginable because some studies have reported several cases with SARS-CoV-2 and influenza virus co-infection. Given the importance of the mentioned co-infection and the coming influenza season, it is essential to recognize the similarities and differences between the symptoms, immunopathogenesis and treatment of SARS-CoV-2 and influenza virus. Therefore, we reviewed the virology, clinical features, and immunopathogenesis of both influenza virus and SARS-CoV-2 and evaluated outcomes in cases with SARS-CoV-2 and influenza virus co-infection.
2019 年冠状病毒病（COVID-19）是由严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2）引起的，自 2019 年 12 月以来一直是全球公共卫生紧急事件，到 2020 年 9 月 24 日为止，全球已有超过 98 万人死亡。SARS-CoV-2 在传播方式、临床特征、相关免疫反应和季节性巧合方面类似于流感病毒。因此，可以想象这两种病毒会同时感染，因为一些研究报告了几例 SARS-CoV-2 和流感病毒同时感染的病例。鉴于这种合并感染的重要性和即将到来的流感季节，有必要认识到 SARS-CoV-2 和流感病毒在症状、免疫发病机制和治疗方面的异同。因此，我们回顾了流感病毒和 SARS-CoV-2 的病毒学、临床特征和免疫发病机制，并评估了 SARS-CoV-2 和流感病毒合并感染病例的结局。
