对映体螺旋二氧化钛纳米纤维调节不同的肽组装及随后的细胞行为。
Enantiomeric helical TiO nanofibers modulate different peptide assemblies and subsequent cellular behaviors.
作者信息
Jie Xu, Xu Deng, Wei Weili
机构信息
School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University Chongqing 401331 China
Chongqing Institute for Food and Drug Control Chongqing 401121 China.
出版信息
RSC Adv. 2019 Sep 17;9(50):29149-29153. doi: 10.1039/c9ra04660g. eCollection 2019 Sep 13.
The effect of the morphological chirality of inorganic TiO nanofibers on peptide assembly and cellular behaviors was investigated. Model peptide insulin maintains its native structure and served as a growth factor for promoting proliferation and differentiation of PC12 cells on the surface of right-handed TiO. In contrast, insulin forms amyloid fibrils and loses its bioactivity on the left-handed TiO.
研究了无机TiO纳米纤维的形态手性对肽组装和细胞行为的影响。模型肽胰岛素保持其天然结构，并作为生长因子促进PC12细胞在右手性TiO表面的增殖和分化。相比之下，胰岛素在左手性TiO上形成淀粉样纤维并失去其生物活性。
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