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[基层医疗中新型冠状病毒肺炎的临床特征:COVIDPAP研究]

[COVID-19 clinical features in primary care: COVIDPAP study].

作者信息

Carballal-Mariño Marta, Balaguer-Martínez Josep Vicent, García-Vera César, Morillo-Gutierrez Beatriz, Domínguez-Aurrecoechea Begoña, Jimenez-Alés Rafael, Gallego-Iborra Ana, Cañavate-González Cristina, Ciriza-Barea Edurne

机构信息

Centro de Atención Primaria «Cerceda-Culleredo», A Coruña, España.

Centro de Atención Primaria «Sant Ildefons», Cornellà de Llobregat, Barcelona, España.

出版信息

An Pediatr (Barc). 2022 Jul;97(1):48-58. doi: 10.1016/j.anpedi.2022.04.006. Epub 2022 May 2.

Abstract

OBJECTIVES

In Spain, the tools to diagnose COVID-19 were available in primary care from May 2020. Previously most studies described inpatients, and fever and cough were the most frequent symptoms. This study aims to define the clinical picture of the pediatric COVID-19 in the community.

METHODS

A descriptive and analytical observational study was performed including pediatric cases (0-14y) from 255 pediatricians, proportionally distributed to its population, from primary health centers in Spain, from 12th May 2020 to 30th April 2021. Diagnostics were made by PCR detection of viral RNA, rapid antigen detection test or positive IgG serology.

RESULTS

There were 10,021 positive children included, 48.4% women, mean age 8,04 ± 4.17 years. Infection was detected due to contact tracing (70.9%), compatible symptoms (18.8%). Household was the main source of transmission (64.9%), followed by school setting (10%) or unknown (9.9%). We did not find any significant differences in the incidence between holidays and school terms. 43.2% of the children were asymptomatic. Most frequent symptoms are rhinorrhea in < 2 y, fever in 3-8 y and headache in > 9 y. An exhaustive description of objective and subjective symptoms by age is made. 18 patients were hospitalized, one with multisystem inflammatory syndrome in children. There were no deaths.

CONCLUSIONS

Pediatric COVID-19 is a mild disease, with a large number of asymptomatic cases, with very few hospital admissions and deaths. The main setting for transmission is the household, and school closures should be a last resource measure during the COVID-19 pandemic. A specific clinical picture of pediatric COVID-19 was not found.

摘要

目的

在西班牙,自2020年5月起初级保健机构便具备诊断新冠病毒病(COVID-19)的工具。此前,大多数研究描述的是住院患者,发热和咳嗽是最常见的症状。本研究旨在明确社区中儿童COVID-19的临床表现。

方法

进行了一项描述性和分析性观察性研究,纳入了来自西班牙初级卫生保健中心的255名儿科医生接诊的儿科病例(0至14岁),按比例分配至其所在人群,研究时间为2020年5月12日至2021年4月30日。诊断通过病毒RNA的聚合酶链反应(PCR)检测、快速抗原检测试验或阳性IgG血清学检测进行。

结果

共纳入10021名阳性儿童,其中48.4%为女性,平均年龄8.04±4.17岁。感染通过接触者追踪检测到(70.9%),有符合症状的(18.8%)。家庭是主要传播源(64.9%),其次是学校环境(10%)或传播源不明(9.9%)。我们未发现假期和学期之间发病率有任何显著差异。43.2%的儿童无症状。最常见的症状在2岁以下儿童中是流鼻涕,3至8岁儿童中是发热,9岁以上儿童中是头痛。按年龄对客观和主观症状进行了详尽描述。18名患者住院治疗,1名患有儿童多系统炎症综合征。无死亡病例。

结论

儿童COVID-19是一种轻症疾病,无症状病例众多,住院和死亡病例极少。主要传播场所是家庭,在COVID-19大流行期间,学校停课应作为最后手段。未发现儿童COVID-19的特定临床表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2eb/9057975/17ffd953c7e0/fx1_lrg.jpg

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