西沙必利长期给药对特发性胃轻瘫患者固体食物胃排空及消化不良症状的影响。
Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis.
作者信息
Corinaldesi R, Stanghellini V, Raiti C, Rea E, Salgemini R, Barbara L
出版信息
Gut. 1987 Mar;28(3):300-5. doi: 10.1136/gut.28.3.300.
Abstract
In a double blind crossover comparison with placebo, the effects of cisapride (10 mg tid for two weeks), a non-antidopaminergic gastrointestinal prokinetic drug, on gastric emptying times and on symptoms were evaluated in 12 patients with chronic idiopathic dyspepsia and gastroparesis. Gastric emptying was studied by a radioisotopic gamma camera technique. The test meal was labelled in the solid component (99mTc-sulphur colloid infiltrated chicken liver). Nine symptoms (nausea, belching, regurgitations, vomiting, postprandial drowsiness, early satiety, epigastric pain or burning, heartburn) were graded weekly on a questionnaire. Cisapride was significantly more effective than placebo in shortening the t1/2 of gastric emptying (p2 = 0.04), but no significant difference was observed between the two treatments with regard to the improvement of total symptom score (p2 = 0.09). No side effects were reported during the study.
摘要
在一项与安慰剂的双盲交叉比较中，对12例慢性特发性消化不良和胃轻瘫患者评估了西沙必利（10毫克，每日三次，共两周）（一种非抗多巴胺能胃肠促动力药物）对胃排空时间和症状的影响。通过放射性同位素γ相机技术研究胃排空。测试餐在固体成分中标记（99mTc-硫胶体浸润鸡肝）。每周通过问卷对九种症状（恶心、嗳气、反流、呕吐、餐后嗜睡、早饱、上腹部疼痛或烧灼感、烧心）进行评分。西沙必利在缩短胃排空t1/2方面比安慰剂显著更有效（p2 = 0.04），但在改善总症状评分方面，两种治疗之间未观察到显著差异（p2 = 0.09）。研究期间未报告副作用。
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本文引用的文献
1
Dyspepsia, antral motor dysfunction, and gastric stasis of solids.消化不良、胃窦运动功能障碍及固体食物胃潴留。
Gastroenterology. 1980 Feb;78(2):360-5.
2
3
Analysis of gastric emptying data.胃排空数据的分析
Gastroenterology. 1982 Dec;83(6):1306-12.
4
Isotope studies in gastric emptying.胃排空的同位素研究。
Dig Dis Sci. 1982 Jun;27(6):571-2. doi: 10.1007/BF01296742.
5
Psychogenic vomiting associated with depression.
Psychosomatics. 1982 Jan;23(1):91-5. doi: 10.1016/S0033-3182(82)70817-5.
6
Drug therapy. Metoclopramide.药物治疗。甲氧氯普胺。
N Engl J Med. 1981 Jul 2;305(1):28-33. doi: 10.1056/NEJM198107023050106.
7
Perturbation of upper gastrointestinal function by cold stress.冷应激对上消化道功能的扰动。
Gut. 1983 Apr;24(4):277-83. doi: 10.1136/gut.24.4.277.
8
Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.多潘立酮。对其药理活性、药代动力学以及在慢性消化不良症状治疗和作为止吐药方面的治疗效果的综述。
Drugs. 1982 Nov;24(5):360-400. doi: 10.2165/00003495-198224050-00002.
9
Stress-induced gastroduodenal motor disturbances in humans: possible humoral mechanisms.应激引起的人类胃十二指肠运动障碍：可能的体液机制。
Gastroenterology. 1983 Jul;85(1):83-91.
10
Effect of opiate and adrenergic blockers on the gut motor response to centrally acting stimuli.阿片类药物和肾上腺素能阻滞剂对肠道运动对中枢性刺激反应的影响。
Gastroenterology. 1984 Nov;87(5):1104-13.
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