Urbain J L, Siegel J A, Debie N C, Pauwels S P
Department of Nuclear Medicine, University of Louvain Medical School, Brussels, Belgium.
Dig Dis Sci. 1988 Jul;33(7):779-83. doi: 10.1007/BF01550963.
The effect of the new gastrokinetic agent cisapride on gastric emptying was evaluated in 17 dyspeptic patients using the dual radionuclide technique. Eight patients with idiopathic dyspepsia and nine postsurgical dyspeptic patients were studied and compared to a control group. Gastric emptying of solids and liquids was determined after ingestion of a standardized meal using 99mTc-sulfur colloid scrambled eggs as the solid phase and [111In]DTPA-labeled water as the liquid phase. Following a basal study and on a separate occasion, each patient received an intravenous bolus of 10 mg of cisapride after ingestion of the test meal; 10 of the patients were restudied after a two-week period of chronic oral administration of the drug (10 mg four times a day). Baseline gastric emptying of solids was significantly delayed in idiopathic and postsurgical patients; liquid emptying was only delayed in the postsurgical group. Intravenous and oral administration of cisapride significantly shortened gastric emptying in both groups. In all but one patient, the clinical improvement was confirmed by the test. Cisapride appears to be a good alternative to metoclopramide and domperiodone in the treatment of dyspeptic patients. The dual radionuclide technique appears to be a useful physiologic tool for evaluating and predicting the efficacy of a gastric prokinetic therapy in man.
采用双放射性核素技术，对17例消化不良患者评估了新型促胃肠动力药西沙必利对胃排空的影响。研究了8例特发性消化不良患者和9例术后消化不良患者，并与一个对照组进行比较。在摄入标准化餐食后，使用99mTc-硫胶体炒鸡蛋作为固相、[111In]二乙三胺五乙酸标记水作为液相，测定固体和液体的胃排空情况。在基础研究之后，且在另一个时间点，每位患者在摄入试验餐食后接受10mg西沙必利静脉推注；10例患者在为期两周的慢性口服该药（每日4次，每次10mg）后再次接受研究。特发性和术后患者的固体基线胃排空显著延迟；液体排空仅在术后组延迟。西沙必利静脉注射和口服均显著缩短了两组的胃排空时间。除1例患者外，所有患者的临床改善均通过试验得到证实。在治疗消化不良患者方面，西沙必利似乎是甲氧氯普胺和多潘立酮的良好替代药物。双放射性核素技术似乎是评估和预测胃促动力疗法对人体疗效的一种有用的生理学工具。
