Baleiras Mafalda Miranda, Graça Joana, Fernandes Leonor, Chorão Martinha, Vasques Ana Carolina, Pinto Marta Mesquita
Department of Medical Oncology, Hospital São Francisco Xavier, Lisbon, Portugal.
Department of Medical Oncology, Hospital Vila Franca de Xira, Vila Franca de Xira, Portugal.
Arch Clin Cases. 2022 Apr 6;9(1):6-11. doi: 10.22551/2022.34.0901.10196. eCollection 2022.
Leptomeningeal carcinomatosis (LMC) is exceedingly rare in gastric cancer. It is most commonly seen in breast, lung cancer and melanoma, and is associated with an extremely poor prognosis. If untreated, median overall survival is four to six weeks. No standard treatment for LMC exists and published data are scarce. We present two cases of gastric carcinoma diagnosed with LMC that exemplify how aggressive this condition is and how short the time lapse is to perform any targeted therapy. This report aims to raise awareness of this rare metastatic possibility in gastric cancer and its diagnostic and therapeutic challenges.
软脑膜癌病（LMC）在胃癌中极为罕见。它最常见于乳腺癌、肺癌和黑色素瘤，且预后极差。若不治疗，总体中位生存期为四至六周。目前尚无LMC的标准治疗方法，且公开数据稀少。我们报告两例诊断为LMC的胃癌病例，以说明这种情况的侵袭性有多强以及进行任何靶向治疗的时间间隔有多短。本报告旨在提高对胃癌这种罕见转移可能性及其诊断和治疗挑战的认识。
