Enhanced Laterality Index: A Novel Measure for Hemispheric Asymmetry.

During sleep, the two hemispheres display asymmetries in their activation pattern. Various hemispheric asymmetry measures have been utilized in existing works. Nevertheless, all these measures have one common problem that they would merely take one representative quantity into account when evaluating the functional asymmetry. However, there is a complex series of information exchanges between the two cerebral hemispheres, and only considering one quantity inevitably leads to one-sided or even incorrect conclusions. Consequently, to address the limitation of conventional laterality indices, we propose the so-called enhanced laterality index (ELI), which considers multiple measures of functional asymmetries. Normal sleep and obstructive sleep apnea electroencephalograms (EEGs) from 21 subjects collected in the clinical acquisition system are applied, and two representative quantities are considered simultaneously in this paper. We measure the signal complexity by using fuzzy entropy, and the signal strength is evaluated by calculating EEG energy. The difference of ELI is demonstrated by the comparison with the traditional laterality index (LI) in evaluating the functional asymmetry during sleep.