Gao Jie, Yang Jianmei, Lu Zhiyuan, Dong Xianwen, Xu Ying
Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, China.
Evid Based Complement Alternat Med. 2022 Apr 29;2022:6813421. doi: 10.1155/2022/6813421. eCollection 2022.
Guizhi Fuling Formulation (GZFL), a traditional Chinese medical formulation, consists of Cinnamomi Ramulus, Paeoniae Radix Alba (or Paeoniae Radix Rubra), Moutan Cortex, Persicae Semen, and Poria, with multiple therapeutic functions such as sedation, antitumor activity, anti-inflammation, and neuroprotection. However, its clinical applications remain relatively fragmented, and the underlying mechanisms of GZFL in different diseases are still not very certain. Further research and summary in both application and mechanisms remain to be needed for human health and the best use of GZFL. Therefore, we summarized the multiple pharmacologic effects and possible mechanisms of action of GZFL according to recent 17 years of research.
We retrieved four English and two Chinese databases using these keywords (the formulation name or its synonyms) and searched articles written in English from January 2006 up to February 2022. . GZFL exhibits multiple pharmacologic advantages in gynecologic diseases and other expanding diseases such as cancer, blood, and vascular disease, renal failure, inflammation, and brain injury. Possibly due to its diverse bioactive components and pharmacologic activities, GZFL could target the multiple signaling pathways involved in regulating blood circulation, inflammatory and immune factors, proliferation, apoptosis, and so on.
This review suggests that GZFL displays promising therapeutic effects for many kinds of diseases, which have been beyond the scope of the original prescription for gynecologic diseases. In this way, we wish to provide a reference and recommendation for further preclinic and clinic studies.
桂枝茯苓方是一种中药方剂，由桂枝、白芍（或赤芍）、牡丹皮、桃仁和茯苓组成，具有多种治疗功能，如镇静、抗肿瘤活性、抗炎和神经保护作用。然而，其临床应用仍相对分散，桂枝茯苓方在不同疾病中的潜在机制仍不太明确。为了人类健康和更好地利用桂枝茯苓方，在应用和机制方面仍需要进一步的研究和总结。因此，我们根据最近17年的研究总结了桂枝茯苓方的多种药理作用和可能的作用机制。
我们使用这些关键词（方剂名称或其同义词）检索了四个英文数据库和两个中文数据库，并搜索了2006年1月至2022年2月期间用英文撰写的文章。桂枝茯苓方在妇科疾病以及其他不断扩展的疾病如癌症、血液和血管疾病、肾衰竭、炎症和脑损伤等方面表现出多种药理优势。可能由于其多样的生物活性成分和药理活性，桂枝茯苓方可以靶向参与调节血液循环、炎症和免疫因子、增殖、凋亡等的多种信号通路。
本综述表明，桂枝茯苓方对多种疾病显示出有前景的治疗效果，这些疾病已经超出了其妇科疾病原方的范围。通过这种方式，我们希望为进一步的临床前和临床研究提供参考和建议。
