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[免疫球蛋白在儿童细菌性脑膜炎治疗中的应用]

[Immunoglobulins in the treatment of bacterial meningitis in childhood].

作者信息

Noack R, Szugs C, Scholz H

出版信息

Infection. 1987 Jan-Feb;15(1):11-5. doi: 10.1007/BF01646110.

Abstract

In a prospective, clinical study forty-four children with bacterial meningitis were treated with antibiotics and underwent a special intravenous treatment with 7-S-immunoglobulins. The children's age ranged between two days and thirteen years. Two of the children died. The other forty-two children did not show any signs of neurological deficiencies upon release from the hospital. The apparently improved prognosis, due to the immunoglobulin therapy, was confirmed by a retrospective study of thirty-six patients, that had an unfavorable prognosis of pneumococcal meningitis. All fourteen patients that had acquired pneumococcal meningitis, and had been treated with immunoglobulins, were clinically cured, whereas in comparison, the sixteen patients of the other group exhibited severe sequelae, and two of them died.

摘要

在一项前瞻性临床研究中,44名患有细菌性脑膜炎的儿童接受了抗生素治疗,并接受了7-S-免疫球蛋白的特殊静脉治疗。这些儿童的年龄在2天至13岁之间。其中两名儿童死亡。其他42名儿童出院时未表现出任何神经功能缺陷的迹象。一项对36例肺炎球菌性脑膜炎预后不良患者的回顾性研究证实,免疫球蛋白治疗明显改善了预后。所有14例患有肺炎球菌性脑膜炎并接受免疫球蛋白治疗的患者均临床治愈,而相比之下,另一组的16例患者出现了严重的后遗症,其中2例死亡。

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