Hitzig W H
Blut. 1980 Mar;40(3):215-24. doi: 10.1007/BF01008579.
The indications for immunoglobulin therapy in childhood have been well established for many years: prophylaxis is effective with single small doses, a full substitution needs multiple large applications. All other recommendations are ill-defined and result from wishful thinking rather than from solid clinical data. New is the possibility of safe i. v. Ig-application which could be realized through appropriate modification of gammaglobulin preparations. Some properties of the commercially available products are summarized. Our own experience with one of them is encouraging: as a matter of fact, fully effective gammaglobulin substitution is now possible in patients with antibody deficiency syndrome.
单次小剂量预防有效，完全替代则需要多次大剂量应用。所有其他建议都不明确，是一厢情愿而非基于可靠的临床数据。新出现的情况是，通过对丙种球蛋白制剂进行适当改良，可以实现安全的静脉注射免疫球蛋白应用。总结了市售产品的一些特性。我们对其中一种产品的自身经验令人鼓舞：事实上，现在抗体缺陷综合征患者已能够实现完全有效的丙种球蛋白替代。
