Tang Tianwei, Liu Yinghuan, Jiang Ying
College of Chemistry, Beijing Normal University, Beijing, 100875 P. R. China.
Beijing National Laboratory for Molecular Sciences, Beijing, 100190 P. R. China.
Chem Res Chin Univ. 2022;38(4):866-878. doi: 10.1007/s40242-022-2084-z. Epub 2022 May 5.
Highly selective, sensitive, and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases. Electrochemical aptamer-based (E-AB) sensor is an appealing platform for measurement in biological system, attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis. This review summarizes the latest development of E-AB sensors, focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system, and then looks forward to the challenges and prospects of the future development of electrochemical aptamer-based sensors.
高选择性、高灵敏度和高稳定性的生物传感器对于在分子水平上理解许多生理活动和疾病至关重要。基于电化学适配体的（E-AB）传感器是生物系统中一种有吸引力的测量平台，这归因于适配体的高选择性和电化学分析的高灵敏度的综合优势。本文综述了E-AB传感器的最新进展，重点介绍了传感器制备中使用的修饰策略以及生物系统中不同大小分析物的传感策略，然后展望了基于电化学适配体的传感器未来发展面临的挑战和前景。
