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基于二维材料的光学生物传感器：现状与展望。

2D Material-Based Optical Biosensor: Status and Prospect.

机构信息

Key Lab of In-Fiber Integrated Optics of Ministry of Education of China, Harbin Engineering University, Harbin, 150001, China.

出版信息

Adv Sci (Weinh). 2022 Feb;9(4):e2102924. doi: 10.1002/advs.202102924. Epub 2021 Dec 13.

DOI:10.1002/advs.202102924
PMID:34898053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8811838/
Abstract

The combination of 2D materials and optical biosensors has become a hot research topic in recent years. Graphene, transition metal dichalcogenides, black phosphorus, MXenes, and other 2D materials (metal oxides and degenerate semiconductors) have unique optical properties and play a unique role in the detection of different biomolecules. Through the modification of 2D materials, optical biosensor has the advantages that traditional sensors (such as electrical sensing) do not have, and the sensitivity and detection limit are greatly improved. Here, optical biosensors based on different 2D materials are reviewed. First, various detection methods of biomolecules, including surface plasmon resonance (SPR), fluorescence resonance energy transfer (FRET), and evanescent wave and properties, preparation and integration strategies of 2D material, are introduced in detail. Second, various biosensors based on 2D materials are summarized. Furthermore, the applications of these optical biosensors in biological imaging, food safety, pollution prevention/control, and biological medicine are discussed. Finally, the future development of optical biosensors is prospected. It is believed that with their in-depth research in the laboratory, optical biosensors will gradually become commercialized and improve people's quality of life in many aspects.

摘要

二维材料与光学生物传感器的结合已成为近年来的热门研究课题。石墨烯、过渡金属二卤化物、黑磷、MXenes 以及其他二维材料（金属氧化物和简并半导体）具有独特的光学性质，在检测不同生物分子方面发挥着独特的作用。通过对二维材料的修饰，光学生物传感器具有传统传感器（如电传感）所不具备的优势，大大提高了灵敏度和检测极限。本文综述了基于不同二维材料的光学生物传感器。首先，详细介绍了生物分子的各种检测方法，包括表面等离子体共振（SPR）、荧光共振能量转移（FRET）和消逝波以及二维材料的性质、制备和集成策略。其次，总结了基于二维材料的各种生物传感器。此外，还讨论了这些光学生物传感器在生物成像、食品安全、污染防治和生物医学中的应用。最后，对光学生物传感器的未来发展进行了展望。相信随着它们在实验室中的深入研究，光学生物传感器将逐渐商业化，并在许多方面提高人们的生活质量。

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