Shi Yesi, Qian Hongyan, Rao Peishi, Mu Dan, Liu Yuan, Liu Gang, Lin Zhongning
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361102, China.
Acta Pharm Sin B. 2022 Mar;12(3):1126-1147. doi: 10.1016/j.apsb.2021.09.025. Epub 2021 Oct 1.
Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases, which involve plenty of immune cells, pathogens and autoantibodies. Nanomedicine has a great potential in modulating immune system. Particularly, biomimetic nanomodulators can be designed for prevention, diagnosis and therapy to achieve a better targeted immunotherapy. With the development of materials science and bioengineering, a wide range of membrane-coated nanomodulators are available. Herein, we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases. We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform, and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.
自身免疫性疾病或感染性疾病常常引发对组织或器官的不良损害，从而触发免疫相关疾病，这些疾病涉及大量免疫细胞、病原体和自身抗体。纳米医学在调节免疫系统方面具有巨大潜力。特别是，可设计仿生纳米调节剂用于预防、诊断和治疗，以实现更好的靶向免疫治疗。随着材料科学和生物工程的发展，出现了多种膜包覆纳米调节剂。在此，我们总结了受生物启发的膜包覆纳米平台在系统性预防免疫相关疾病（包括自身免疫性疾病和感染性疾病）方面的最新进展。我们还重新思考了治疗性纳米平台进展中的挑战或局限性，并从转化医学的角度讨论了纳米调节剂在对抗免疫相关疾病中的进一步应用。
