Department of Biotechnology, National Institute of Technology, Warangal - 506004, TS, India.
Warsaw University of Life Sciences, Warsaw, Poland.
Nanomedicine (Lond). 2017 Nov;12(21):2677-2692. doi: 10.2217/nnm-2017-0225. Epub 2017 Oct 2.
Cell membrane coated nanoparticles (NPs) is a biomimetic strategy developed to engineer therapeutic devices consisting of a NP core coated with membrane derived from natural cells such as erythrocytes, white blood cells, cancer cells, stem cells, platelets or bacterial cells. These biomimetic NPs have gained a lot of attention recently owing to their cell surface mimetic features and tailored nanomaterial characteristics. They have shown strong potential in diagnostic and therapeutic applications including those in drug delivery, immune modulation, vaccination and detoxification. Herein we review the various types of cell membrane coated NPs reported in the literature and the unique strengths of these biomimetic NPs with an emphasis on how these bioinspired camouflage strategies have led to improved therapeutic efficacy. We also highlight the recent progress made by each platform in advancing healthcare and precis the major challenges associated with these NPs.
细胞膜包覆纳米颗粒 (NPs) 是一种仿生策略，用于设计治疗设备，这些设备由 NP 核心包覆来自天然细胞（如红细胞、白细胞、癌细胞、干细胞、血小板或细菌细胞）的膜组成。这些仿生 NPs 由于其细胞表面模拟特性和定制纳米材料特性而受到广泛关注。它们在诊断和治疗应用中显示出巨大的潜力，包括药物输送、免疫调节、疫苗接种和解毒。本文综述了文献中报道的各种类型的细胞膜包覆 NPs，以及这些仿生 NPs 的独特优势，重点介绍了这些仿生伪装策略如何提高治疗效果。我们还强调了每个平台在推进医疗保健方面取得的最新进展，并指出了与这些 NPs 相关的主要挑战。
