Sharma Poonam, Rohilla Sandeep, Jain Nidhi
Department of Chemistry, Indian Institute of Technology, Delhi, India 110016.
J Org Chem. 2015 Apr 17;80(8):4116-22. doi: 10.1021/acs.joc.5b00443. Epub 2015 Mar 31.
An unprecedented copper acetate-DMSO promoted methylthiolation of arenes and heteroarenes in the presence of air has been developed. The reaction is highly regioselective under the directing group influence of pyridine and pyrimidine functional units and gives the thiomethylated product in moderate to high yields.
已开发出一种前所未有的在空气中醋酸铜 - 二甲基亚砜促进的芳烃和杂芳烃的甲硫基化反应。该反应在吡啶和嘧啶官能团的导向基团影响下具有高度区域选择性，并以中等至高收率得到甲硫基化产物。
