肽聚糖途径：还有更多！

Helal Ahmed M, Sayed Ahmed M, Omara Mariam, Elsebaei Mohamed M, Mayhoub Abdelrahman S

Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University Cairo 11884 Egypt

University of Science and Technology, Zewail City of Science and Technology Giza Egypt.

RSC Adv. 2019 Sep 9;9(48):28171-28185. doi: 10.1039/c9ra04518j. eCollection 2019 Sep 3.

The discovery of 3 and 4 generations of currently existing classes of antibiotics has not hindered bacterial resistance, which is escalating at an alarming global level. This review follows WHO recommendations through implementing new criteria for newly discovered antibiotics. These recommendations focus on abandoning old scaffolds and hitting new targets. In light of these recommendations, this review discusses seven bacterial proteins that no commercial antibiotics have targeted yet, alongside their reported chemical scaffolds.

目前存在的第三代和第四代抗生素的发现并未阻碍细菌耐药性，全球范围内细菌耐药性正以惊人的速度升级。本综述遵循世界卫生组织的建议，通过为新发现的抗生素实施新的标准。这些建议侧重于摒弃旧的化学结构并寻找新的靶点。鉴于这些建议，本综述讨论了七种尚未有商业抗生素针对的细菌蛋白，以及它们已报道的化学结构。