Nedzlek Christopher D, Michaelis Anthony
Emergency Medicine, Henry Ford Health System, Wyandotte, USA.
Cureus. 2022 Apr 7;14(4):e23913. doi: 10.7759/cureus.23913. eCollection 2022 Apr.
Phenibut (β-phenyl-γ-aminobutyric acid), a nootropic, gamma-aminobutyric acid receptor agonist, commercially marketed for anxiolysis, is increasingly recognized for its recreational abuse potential. We present the case of a 30-year-old-male with a history of polysubstance abuse, anxiety, and depression, who presented to the Emergency Department by ambulance for altered mental status with severe agitation, requiring both sedation and mechanical ventilation. It was later discovered that he had consumed phenibut, which he purchased through the internet. Currently, no readily available confirmatory laboratory tests exist to aid in the diagnosis of acute phenibut intoxication. We highlight the clinical distinctions between features of acute phenibut intoxication and withdrawal.
苯乙胺（β-苯基-γ-氨基丁酸）是一种促智药，γ-氨基丁酸受体激动剂，在商业上用于抗焦虑治疗，但其娱乐性滥用潜力越来越受到关注。我们报告一例30岁男性病例，该患者有多种物质滥用、焦虑和抑郁病史，因精神状态改变伴严重躁动由救护车送至急诊科，需要镇静和机械通气。后来发现他服用了通过互联网购买的苯乙胺。目前，尚无现成的确诊实验室检查可用于辅助急性苯乙胺中毒的诊断。我们强调了急性苯乙胺中毒和戒断症状之间的临床区别。
