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Dissociative Intoxication and Prolonged Withdrawal Associated With Phenibut: A Case Report.与苯乙胺酪酸相关的分离性中毒和长期戒断：一例报告
J Clin Psychopharmacol. 2017 Aug;37(4):478-480. doi: 10.1097/JCP.0000000000000731.
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[Phenibut yielded withdrawal symptoms and psychosis. Drugs for cosmonauts--now marketed as dietary supplements online].[苯乙胺产生戒断症状和精神病。宇航员用药——现在在网上作为膳食补充剂销售]
Lakartidningen. 2013;110(16):825-7.
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Detoxification of a Patient With Comorbid Dependence on Phenibut and Benzodiazepines by Tapering With Baclofen: Case Report.通过逐渐减少巴氯芬用量对合并使用苯乙胺丁酯和苯二氮䓬类药物成瘾患者进行脱毒治疗：病例报告
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Phenibut dependence.苯乙胺酪酸依赖
BMJ Case Rep. 2013 Feb 6;2013:bcr2012008381. doi: 10.1136/bcr-2012-008381.
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Case Report of Physiologic Phenibut Dependence Treated With a Phenobarbital Taper in a Patient Being Treated With Buprenorphine.丁丙诺啡治疗患者中使用苯巴比妥逐渐减量治疗生理性苯乙哌啶依赖的病例报告
J Addict Med. 2017 May/Jun;11(3):239-240. doi: 10.1097/ADM.0000000000000303.
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[Use of phenibut in France: report of two cases].[苯乙胺在法国的使用：两例报告]
Therapie. 2013 Mar-Apr;68(2):123-4. doi: 10.2515/therapie/2013014. Epub 2013 Jun 18.
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A systematic review of phenibut withdrawal focusing on complications, therapeutic approaches, and single substance versus polysubstance withdrawal.苯环利定戒断的系统回顾：关注并发症、治疗方法以及单一物质与多种物质戒断。
Clin Toxicol (Phila). 2023 Nov;61(11):941-951. doi: 10.1080/15563650.2023.2285702. Epub 2023 Dec 19.
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A Withdrawal Syndrome After a Switch of Phenibut to Another γ-Aminobutyric Acid Agonist.从苯乙胺换成另一种γ-氨基丁酸激动剂后的戒断综合征。
J Clin Psychopharmacol. 2022;42(5):500-501. doi: 10.1097/JCP.0000000000001578. Epub 2022 Aug 6.
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Baclofen and gamma-hydroxybutyrate withdrawal.巴氯芬和γ-羟基丁酸戒断反应。
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Backpedaling on Baclofen: Highlighting Concerns Surrounding Baclofen Use in Phenibut Withdrawal: Letter to the Editor Response.关于巴氯芬的退缩：强调在苯乙胺戒断中使用巴氯芬的相关问题：致编辑的信及回复
J Clin Pharmacol. 2024 Sep;64(9):1183-1184. doi: 10.1002/jcph.2480. Epub 2024 Jun 4.

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1
A Systematic Review of Phenibut Withdrawals.苯乙胺戒断的系统评价
Cureus. 2024 Sep 6;16(9):e68775. doi: 10.7759/cureus.68775. eCollection 2024 Sep.
2
An Unusual Presentation of an Uncommon Drug: A Case Report on Phenibut Overdose.一种不常见药物的异常表现：苯乙胺酪酸过量病例报告
Cureus. 2022 Apr 7;14(4):e23913. doi: 10.7759/cureus.23913. eCollection 2022 Apr.
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Phenibut Addiction in a Patient with Substance Use Disorder.一名患有物质使用障碍患者的苯乙胺γ-氨基丁酸成瘾情况。
Cureus. 2019 Jul 24;11(7):e5230. doi: 10.7759/cureus.5230.
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Phenibut (β-Phenyl-γ-Aminobutyric Acid): an Easily Obtainable "Dietary Supplement" With Propensities for Physical Dependence and Addiction.苯丙哌林（β-苯丙氨酸-γ-氨基丁酸）：一种容易获得的“膳食补充剂”，具有身体依赖和成瘾的倾向。
Curr Psychiatry Rep. 2019 Mar 9;21(4):23. doi: 10.1007/s11920-019-1009-0.
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Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.急性苯海索戒断：全面文献回顾及病例报告
Bosn J Basic Med Sci. 2019 May 20;19(2):125-129. doi: 10.17305/bjbms.2018.4008.
6
Phenibut (-Phenyl--aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse.苯乙胺酪酸（β-苯基-γ-氨基丁酸）依赖与戒断管理：新型滥用益智药
Case Rep Psychiatry. 2018 Apr 30;2018:9864285. doi: 10.1155/2018/9864285. eCollection 2018.

本文引用的文献

1
Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity.苯乙胺（4-氨基-3-苯基丁酸）：可得性、使用流行情况、预期效果及急性毒性。
Drug Alcohol Rev. 2016 Sep;35(5):591-6. doi: 10.1111/dar.12356. Epub 2015 Dec 23.
2
R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects.R-苯丁胺与电压依赖性钙通道的α2-δ亚基结合，并发挥类似加巴喷丁的抗伤害感受作用。
Pharmacol Biochem Behav. 2015 Oct;137:23-9. doi: 10.1016/j.pbb.2015.07.014. Epub 2015 Jul 31.
3
Acute behavioural disturbance associated with phenibut purchased via an internet supplier.通过互联网供应商购买的苯乙胺引起的急性行为障碍。
Clin Toxicol (Phila). 2015;53(7):636-8. doi: 10.3109/15563650.2015.1059945. Epub 2015 Jun 26.
4
Analytically confirmed recreational use of Phenibut (β-phenyl-γ-aminobutyric acid) bought over the internet.经分析确认，通过互联网购买的苯乙胺（β-苯基-γ-氨基丁酸）用于非医疗目的。
Clin Toxicol (Phila). 2015;53(7):783-4. doi: 10.3109/15563650.2015.1059944. Epub 2015 Jun 24.
5
Phenibut, the appearance of another potentially dangerous product in the United States.苯乙胺，美国又一种潜在危险产品的出现。
Am J Med. 2014 Aug;127(8):e3-4. doi: 10.1016/j.amjmed.2014.03.029. Epub 2014 Apr 5.
6
Phenibut dependence.苯乙胺酪酸依赖
BMJ Case Rep. 2013 Feb 6;2013:bcr2012008381. doi: 10.1136/bcr-2012-008381.
7
Withdrawal symptoms after Internet purchase of phenibut (β-phenyl-γ-aminobutyric acid HCl).网购苯乙胺（盐酸β-苯基-γ-氨基丁酸）后的戒断症状。
J Clin Psychopharmacol. 2010 Oct;30(5):648-9. doi: 10.1097/JCP.0b013e3181f057c8.
8
Comparative pharmacological activity of optical isomers of phenibut.苯乙哌啶酮光学异构体的比较药理活性。
Eur J Pharmacol. 2008 Mar 31;583(1):128-34. doi: 10.1016/j.ejphar.2008.01.015. Epub 2008 Jan 26.
9
Psychiatric complications of anabolic steroid abuse.合成代谢类固醇滥用的精神科并发症。
Psychosomatics. 2005 Jul-Aug;46(4):285-90. doi: 10.1176/appi.psy.46.4.285.
10
Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.苯乙胺（β-苯基-GABA）：一种镇静剂和益智药。
CNS Drug Rev. 2001 Winter;7(4):471-81. doi: 10.1111/j.1527-3458.2001.tb00211.x.

Dissociative Intoxication and Prolonged Withdrawal Associated With Phenibut: A Case Report.

作者信息

Joshi Yash B, Friend Samantha F, Jimenez Berenice, Steiger Louisa R

机构信息

Department of Psychiatry, University of California, San Diego, La Jolla, CA.

出版信息

J Clin Psychopharmacol. 2017 Aug;37(4):478-480. doi: 10.1097/JCP.0000000000000731.

DOI:10.1097/JCP.0000000000000731
PMID:28614159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5662439/
Abstract
摘要