Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against and molecular docking studies.

The pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, H NMR, C NMR, mass spectrometry, and elemental analysis. Synthesized compounds () were evaluated for larvicidal activities. Compound (LD: 26.06 µg/mL), and (LD: 26.89 µg/mL), and were notably more active against than permethrin (LD: 26.14 µg/mL). The docking studies also demonstrated that and are potent larvicides with higher binding energy (-12.6 kcal/mol) than the control in the mosquito odorant binding protein (PDB ID: 3OGN). The larvicidal properties of lead molecules have made them important for use as insecticides.