Poyraz Samet, Döndaş H Ali, Döndaş Naciye Yaktubay, Sansano José M
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Çukurova University, Adana, Türkiye.
Department of Biotechnology, Institute of Natural and Applied Sciences, Çukurova University, Adana, Türkiye.
Front Pharmacol. 2023 Sep 6;14:1239658. doi: 10.3389/fphar.2023.1239658. eCollection 2023.
To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents. Their key roles in pharmacotherapy make them a versatile scaffold for designing and developing novel biologically active compounds and drug candidates. This review aims to provide an overview of recent advancements (especially during 2015-2023) in the exploration of pyrrolidine derivatives, emphasizing their significance as fundamental components of the skeletal structure. In contrast to previous reviews that have predominantly focused on a singular biological activity associated with these molecules, this review consolidates findings from various investigations encompassing a wide range of important activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition) exhibited by pyrrolidine derivatives. This study is also anticipated to serve as a valuable resource for drug research and development endeavors, offering significant insights and guidance.
为克服众多健康问题，人们利用了合成或天然来源的杂环结构，值得注意的是，用于治疗的现有药物出现的各种副作用或致病微生物的耐药性使药物失效。因此，发现利用不同作用方式的潜在治疗剂对于规避这些限制至关重要。吡咯烷、吡咯烷生物碱和基于吡咯烷的杂化分子存在于许多天然产物和具有药理学重要性的药物中。它们在药物治疗中的关键作用使其成为设计和开发新型生物活性化合物和候选药物的通用骨架。本综述旨在概述吡咯烷衍生物探索方面的最新进展（特别是在2015 - 2023年期间），强调它们作为骨架结构基本组成部分的重要性。与以往主要关注与这些分子相关的单一生物活性的综述不同，本综述整合了各种研究的结果，这些研究涵盖了吡咯烷衍生物所表现出的广泛重要活性（抗菌、抗病毒、抗癌、抗炎、抗惊厥、胆碱酯酶抑制和碳酸酐酶抑制）。本研究还预期将成为药物研发工作的宝贵资源，提供重要的见解和指导。
