The cultivable endophytic fungal community of : diversity and relevance to flavonoid production by the host.

(), a traditional Chinese medicinal plant, is widely used because of its important pharmacological activities. However, the endophytic fungi that promote flavonoid accumulation in remain unclear. Therefore, we analyzed the endophytic fungal community of and screened the endophytic fungi that might promote flavonoid synthesis in . ITS1/ITS4Blast was used to identify the endophytic fungi in . In total, 687 strains were identified in 57 genera. The dominant genus in the leaves and stems was and that in the roots was was the dominant genus in collected from all sites and in wild and cultivated . Alpha diversity indexes indicated more abundant endophytic fungi in samples from Chengde, the genuine producing area of , than in those from other sites. Beta diversity index analysis indicated that plants with closer geographical relationships showed more similar endophytic fungal community profiles. Spearman correlation analysis revealed that baicalin, wogonoside, wogonin, and oroxylin A contents were significantly correlated with the relative abundance of . Overall, the results indicate the importance of geographical factors in influencing the endophytic fungal community of and suggest that the presence of spp. might contribute to flavonoid synthesis in