评估多米尼加共和国圣地亚哥的 HIV 感染者抑制病毒的障碍。

Evaluating Barriers to Viral Suppression among People with HIV in Santiago, Dominican Republic.

机构信息

12321Brown University, Providence, RI, USA.

Pontificia Universidad Catolica Madre y Maestra, Santiago, DR.

出版信息

J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221096522. doi: 10.1177/23259582221096522.

DOI:10.1177/23259582221096522

PMID:35532067

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9092578/

Abstract

The Dominican Republic (DR) has the second-highest prevalence of HIV infection in the Caribbean, but viral suppression and treatment adherence are not well understood. We conducted a cross-sectional study among people living with HIV/AIDS(PLWHA) to fill in the knowledge gap. Questionnaire was used to collect demographic data, antiretroviral therapy (ART) adherence, and barriers and facilitators to HIV care. Viral load and other clinical information were extracted through chart reviews. Descriptive analyzes and logistic regression were conducted to explore factors associated with non-viral suppression and imperfect ART adherence. Of 193 PLWHA 83.9% were virally suppressed. Those that were non-virally suppressed were more likely of being male (odds ratio [OR]: 2.55, 95% confidence interval [CI]: 1.17-5.58) and less likely of being unemployed (OR: 0.28, 95% CI: 0.08-0.96). However, being male (OR: 0.78, 95% CI:0.40-1.53) and unemployed (OR: 0.28, 95% CI:0. 08-1.21) were less likely to report imperfect adherence. Tailored interventions are needed to improve adherence and viral suppression in DR.

摘要

多米尼加共和国（DR）是加勒比地区艾滋病毒感染率第二高的国家，但病毒抑制和治疗依从性情况并不清楚。我们对艾滋病毒感染者/艾滋病患者（PLWHA）进行了一项横断面研究，以填补这一知识空白。问卷调查用于收集人口统计学数据、抗逆转录病毒治疗（ART）依从性以及艾滋病毒护理的障碍和促进因素。通过病历回顾提取病毒载量和其他临床信息。采用描述性分析和逻辑回归方法，探讨与非病毒抑制和不完美 ART 依从性相关的因素。在 193 名 PLWHA 中，83.9%的病毒得到抑制。未达到病毒抑制的患者更有可能是男性（比值比 [OR]：2.55，95%置信区间 [CI]：1.17-5.58），不太可能失业（OR：0.28，95% CI：0.08-0.96）。然而，男性（OR：0.78，95% CI：0.40-1.53）和失业（OR：0.28，95% CI：0.08-1.21）不太可能报告不完美的依从性。需要有针对性的干预措施来提高多米尼加共和国的依从性和病毒抑制率。