J Drugs Dermatol. 2022 May 1;21(5):517-520. doi: 10.36849/JDD.6503.
Background: Skin exposure to ultraviolet radiation (UVR) causes DNA damage, which can lead to mutagenesis, carcinogenesis, cellular death, and photoaging. Signs of photoaging include wrinkling, erythema, skin laxity, uneven skin texture, and hyperpigmentation. Photolyase is an exogenous DNA repair enzyme that can restore DNA integrity when applied topically to human skin. Antioxidants also play a key role in reducing UVR-associated molecular damage.
To assess the efficacy and safety of a tinted mineral-based sunscreen containing 10.7% zinc oxide (SPF50) with the active ingredients photolyase, antioxidants (Peptide Q10), and peptides in both protecting and repairing signs of photoaging.
In an open-label, single-center, 12-week study, patients aged 35–55 years and Fitzpatrick skin phototypes II–IV applied the sunscreen daily for 84 days. VISIA photography was performed at baseline as well as 6- and 12-week follow-ups. At each visit, the investigator and subject evaluated clinical photoaging parameters including overall photodamage, fine lines/wrinkles, coarse lines/wrinkles, skin tone evenness, tactile roughness, and radiance.
The Investigator Global Aesthetic Improvement Scale (IGAIS) found that 63% of patients showed improvement at week 6 and 81% at week 12. The Subject Global Aesthetic Improvement Scale (SGAIS) showed 58% and 62.5% of patients reported the appearance of their skin was improved at week 6 and 12, respectively. Overall, there was a statistically significant improvement in skin radiance as well as improvement in overall facial aesthetics reported by both investigators and subjects.
This tinted mineral based SPF50 sunscreen containing photolyase, antioxidants, and peptides is effective at repairing some clinical signs of photoaging and is well-tolerated for daily use. J Drugs Dermatol. 2022;21(5):517-520. doi:10.36849/JDD.6503.
皮肤暴露于紫外线辐射（UVR）会导致 DNA 损伤，从而导致突变、致癌、细胞死亡和光老化。光老化的迹象包括皱纹、红斑、皮肤松弛、不均匀的皮肤纹理和色素沉着。光解酶是一种外源性 DNA 修复酶，当局部应用于人体皮肤时，可以恢复 DNA 完整性。抗氧化剂在减少与 UVR 相关的分子损伤方面也起着关键作用。
评估含有 10.7%氧化锌（SPF50）的有色矿物基防晒霜在保护和修复光老化迹象方面的功效和安全性，该防晒霜含有光解酶、抗氧化剂（肽 Q10）和肽等活性成分。
在一项开放标签、单中心、12 周的研究中，年龄在 35-55 岁之间、皮肤光型 II-IV 的患者每天使用防晒霜 84 天。在基线以及 6 周和 12 周的随访中进行 VISIA 摄影。每次就诊时，研究者和受试者评估临床光老化参数，包括整体光损伤、细纹/皱纹、粗纹/皱纹、肤色均匀度、触觉粗糙度和光泽度。
研究者整体美学改善量表（IGAIS）发现，63%的患者在第 6 周时改善，81%的患者在第 12 周时改善。受试者整体美学改善量表（SGAIS）显示，分别有 58%和 62.5%的患者在第 6 周和第 12 周报告其皮肤外观得到改善。总体而言，皮肤光泽度有统计学意义的改善，且研究者和受试者均报告整体面部美学得到改善。
这种含有光解酶、抗氧化剂和肽的有色矿物基 SPF50 防晒霜可有效修复光老化的某些临床迹象，且每天使用耐受性良好。J 皮肤病学杂志。2022;21(5):517-520。doi:10.36849/JDD.6503.
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