对乙酰氨基酚的肝脏效应。在酗酒者中增强的毒性。
Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.
作者信息
Maddrey W C
出版信息
J Clin Gastroenterol. 1987 Apr;9(2):180-5. doi: 10.1097/00004836-198704000-00014.
Abstract
Alcoholic patients run an increased risk of developing hepatotoxicity from doses of acetaminophen within or only moderately above the recommended usual therapeutic doses. In this review I examine the scientific evidence and clinical observations that indicate such a heightened susceptibility of the alcoholic to acetaminophen-induced injury.
摘要
酒精性肝病患者服用对乙酰氨基酚的剂量在推荐的常规治疗剂量范围内或仅略高于该剂量时，发生肝毒性的风险会增加。在这篇综述中，我研究了科学证据和临床观察结果，这些证据和观察结果表明酒精性肝病患者对对乙酰氨基酚所致损伤的易感性增强。
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