Szilagyi A
J Clin Gastroenterol. 1987 Apr;9(2):189-93. doi: 10.1097/00004836-198704000-00016.
Alcoholic liver disease shares with other nonthyroidal illnesses patterns of serum thyroid hormones that usually do not reflect true thyroid function. Although ethanol can affect the thyroid gland and also may directly interfere with thyroid hormone metabolism, most patients with alcoholic liver disease are euthyroid. However, some have mild hypothalamic pituitary axis dysfunction. In persons who chronically and continuously drink alcohol, there are demonstrable biochemical abnormalities similar to the effects of thyroid hormone on the liver. However, a primary pathogenetic role in alcoholic hepatitis has not been proven for this thyroid hormone mimicry. There is good clinical evidence, however, that serum thyroid hormones can serve as prognostic indicators of the course of liver disease.
酒精性肝病与其他非甲状腺疾病一样，具有血清甲状腺激素模式，这些模式通常不能反映真正的甲状腺功能。虽然乙醇可影响甲状腺，也可能直接干扰甲状腺激素代谢，但大多数酒精性肝病患者甲状腺功能正常。然而，一些患者存在轻度下丘脑-垂体轴功能障碍。在长期持续饮酒的人群中，存在与甲状腺激素对肝脏影响类似的可证实的生化异常。然而，这种甲状腺激素模拟作用在酒精性肝炎中的主要致病作用尚未得到证实。不过，有充分的临床证据表明，血清甲状腺激素可作为肝病病程的预后指标。
