Effects of ethanol on protein synthesis and secretion.

Liver protein synthesis involves a complex series of reactions which is influenced by hormones, nutritional state and general health of an animal. The secretory processes for proteins, such as albumin, also interact with the protein synthetic machinery of the liver. Alcohol may affect synthesis and/or secretion at a number of loci and the mechanism of alcohol's action could depend on the immediate state of the experimental tissue. Ethanol was shown to interfere with albumin synthesis and the effect was shown to differ when livers from fed and fasted animals were compared. The ethanol effects were also dependent on the metabolism of ethanol rather than on the simple presence of this drug. Acetaldehyde decreased albumin synthesis but in a manner which was distinct from the ethanol effect. Acute ethanol administration under the conditions used in our studies had little effect on secretion of prelabeled proteins from hepatocytes. The implications of studies of the effects of ethanol on liver protein synthesis and secretion are discussed.