Klemparskaya N N, Pinegin B V, Shal'nova G A, Korshunov V M, Mal'tsev V N, Glad'ko I A, Kuz'mina T D, Ulanova A M, Dobronravova N N, Yermolov V V
J Hyg Epidemiol Microbiol Immunol. 1987;31(1):91-8.
It has been demonstrated in experiments on 2160 CBA mice and mice of mixed breed, irradiated by LD90/30, that therapeutical administration (subcutaneous or intraperitoneal) of immunoglobulins - homologous (polyglobulin, IgG, IgM) or heterologous - polyglobulin, IgG (from human, equine, canine blood) repeated three times, i.e., 2, 24 and 48 hours after irradiation, not only induces longer survival, but also shows a normalizing effect on the commonly developing dysbacteriosis and increased amount of intestinal microflora and, in addition, leads to suppression of postirradiation endogenous infection. Enterobacteria, enterococci, staphylococci, yeasts, disappear from the small intestine or their quantity decreases substantially in treated irradiated mice in contrast to untreated irradiated mice. In the large intestine, the amount of these organisms decreases considerably while the content of lactobacteria increases; no microbes can be found in the internal organs and in blood (or their content is small). Other conditions being equal, homologous immunoglobulins are more efficient in comparison with heterologous, this applying also to preparations containing normal antibodies to tissues.
在对2160只CBA小鼠和杂种小鼠进行的实验中，这些小鼠接受了LD90/30剂量的照射，结果表明，在照射后2、24和48小时重复三次进行免疫球蛋白的治疗性给药（皮下或腹腔注射）——同源的（多球蛋白、IgG、IgM）或异源的——多球蛋白、IgG（来自人、马、犬的血液），不仅能延长存活时间，还对通常会发生的菌群失调和肠道微生物数量增加具有正常化作用，此外，还能抑制照射后的内源性感染。与未治疗的受照射小鼠相比，肠杆菌、肠球菌、葡萄球菌、酵母菌从小肠中消失或其数量在接受治疗的受照射小鼠中大幅减少。在大肠中，这些微生物的数量大幅减少，而乳酸菌的含量增加；在内脏和血液中未发现微生物（或其含量很少）。在其他条件相同的情况下，同源免疫球蛋白比异源免疫球蛋白更有效，这也适用于含有针对组织的正常抗体的制剂。
