Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
Department of Biosciences, School of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
Immunobiology. 2022 May;227(3):152222. doi: 10.1016/j.imbio.2022.152222. Epub 2022 May 4.
The million-dollar question that has been the talk of the day is how effective the COVID 19 vaccines are against the Omicron variant. Still, there is no clear-cut answer to this question but several studies have concluded that this Variant of Concern (VOC) successfully weakens the neutralizing capability of the antibodies acquired from the COVID 19 vaccines and prior infections, which indicates that Omicron can easily bypass an individual's humoral immune response. However, the most significant confusion revolves around cell-mediated immunity tackling the Omicron variant. This paper aims to provide a clear idea about the status of the body's immune surveillance concerning the infection caused by the Omicron variant by producing the effectivity of the humoral and cell-mediated immunity in handling the same. This work also provides complete detail of the various characteristics of the Omicron variant and how it may be a blessing in disguise. The effectiveness of the current vaccines, the transmissibility rate of the variant compared to the other variants, and the importance of administering a booster dose to prevent the spread of this variant are also discussed. Finally, this work aims to bridge the gap between the past and the current status of the Omicron infection and sheds light on the hypothetical idea that herd immunity developed from the SARS-COV2 infection may help tackle other dangerous variants.
目前人们热议的焦点问题是，新冠疫苗对奥密克戎变异株的有效性如何。但对于这个问题，目前尚无明确答案。不过，有几项研究的结论表明，这种关注的变异株（VOC）成功削弱了新冠疫苗和既往感染产生的抗体的中和能力，这表明奥密克戎可以轻易绕过个体的体液免疫反应。然而，最大的困惑集中在针对奥密克戎变异株的细胞介导免疫上。本文旨在通过研究体液和细胞介导免疫对奥密克戎变异株感染的作用效果，提供关于机体免疫监测对奥密克戎变异株感染状况的清晰认识。本文还详细介绍了奥密克戎变异株的各种特征，以及它可能是因祸得福的原因。此外，还讨论了目前疫苗的有效性、该变异株与其他变异株相比的传染性以及接种加强针以防止该变异株传播的重要性。最后，本文旨在弥合奥密克戎感染过去和现状之间的差距，并提出一个假设性的观点，即从 SARS-COV2 感染中产生的群体免疫可能有助于应对其他危险的变异株。
