COVID-19 和视网膜退行性疾病：有希望的联系“山奈酚”。
COVID-19 and retinal degenerative diseases: Promising link "Kaempferol".
机构信息
Apoptosis and Cell Survival Research Laboratory, 412G Pearl Research Park, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Apoptosis and Cell Survival Research Laboratory, 412G Pearl Research Park, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
出版信息
Curr Opin Pharmacol. 2022 Jun;64:102231. doi: 10.1016/j.coph.2022.102231. Epub 2022 Apr 14.
Coronavirus disease (COVID-19) outbreak has caused unprecedented global disruption since 2020. Approximately 238 million people are affected worldwide where the elderly succumb to mortality. Post-COVID syndrome and its side effects have popped up with several health hazards, such as macular degeneration and vision loss. It thus necessitates better medical care and management of our dietary practices. Natural flavonoids have been included in traditional medicine and have also been used safely against COVID-19 and several other diseases. Kaempferol is an essential flavonoid that has been demonstrated to influence several vital cellular signaling pathways involved in apoptosis, angiogenesis, inflammation, and autophagy. In this review, we emphasize the plausible regulatory effects of Kaempferol on hallmarks of COVID-19 and macular degeneration.
自 2020 年以来，冠状病毒病（COVID-19）的爆发造成了前所未有的全球混乱。全世界约有 2.38 亿人受到影响，老年人死亡率较高。COVID-19 后综合征及其副作用带来了多种健康危害，如黄斑变性和视力丧失。因此，有必要更好地进行医疗护理和管理我们的饮食。天然类黄酮已被纳入传统医学，并已安全用于对抗 COVID-19 和其他几种疾病。山柰酚是一种重要的类黄酮，已被证明可影响细胞凋亡、血管生成、炎症和自噬等几个重要的细胞信号通路。在这篇综述中，我们强调了山柰酚对 COVID-19 和黄斑变性特征的可能调节作用。
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