Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA 78712.
Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA 78712.
Curr Opin Struct Biol. 2022 Jun;74:102385. doi: 10.1016/j.sbi.2022.102385. Epub 2022 Apr 11.
Antigen design guided by high-resolution viral glycoprotein structures has successfully generated diverse vaccine candidates for COVID-19. Using conjugation systems to combine antigen design with computationally optimized nanoparticles, researchers have been able to display multivalent antigens with beneficial substitutions that elicited robust humoral immunity with enhanced neutralization potency and breadth. Here, we discuss strategies that have been used for structure-based design and nanoparticle display to develop COVID-19 vaccine candidates as well as potential next-generation vaccine candidates to protect against SARS-CoV-2 variants and other coronaviruses that emerge into the human population.
基于高分辨率病毒糖蛋白结构的抗原设计成功地为 COVID-19 生成了多种疫苗候选物。研究人员使用缀合系统将抗原设计与经过计算优化的纳米颗粒结合，从而能够展示具有有益取代的多价抗原，这些抗原引发了强大的体液免疫，增强了中和效力和广度。在这里，我们讨论了用于基于结构的设计和纳米颗粒展示的策略，以开发 COVID-19 疫苗候选物以及潜在的下一代疫苗候选物，以预防 SARS-CoV-2 变体和其他进入人类群体的冠状病毒。
