Chen Zhe, Xiao Wei, Peng Tao, Ye Linfeng
Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ear Nose Throat J. 2025 Feb;104(2):NP50-NP53. doi: 10.1177/01455613221083810. Epub 2022 May 9.
Inflammatory myofibroblastic tumor (IMT) is a very rare mesenchymal tumor that can behave as a locally benign or aggressive lesion. Here, we present an extremely rare case of IMT involving the subglottic of a middle-aged male. Steroid therapy treatment alleviated dyspnea, but the recurrence of dyspnea was reported two months later. Both sides of the subglottic tumor were excised following treatment, and the surgical specimens were subjected to histopathological evaluation and diagnosis for IMT. At 4 years after excision, follow-up laryngoscopy revealed symmetric vocal cords without evidence of any subglottic mass. Subglottic mass is often asymptomatic until it presents with hoarseness or dyspnea, and subglottic IMT is rare. Based on the successful treatment of our case, complete surgical excision is highly recommended for this rare tumor. However, further research is needed to discover a more effective and cost-effective treatment approach.
炎性肌纤维母细胞瘤(IMT)是一种非常罕见的间叶性肿瘤,其表现可为局部良性或侵袭性病变。在此,我们报告一例极其罕见的累及中年男性声门下区的IMT病例。类固醇治疗缓解了呼吸困难,但两个月后报告呼吸困难复发。治疗后切除了声门下肿瘤的双侧,手术标本进行了组织病理学评估及IMT诊断。切除术后4年,随访喉镜检查显示声带对称,未发现声门下肿物。声门下肿物通常无症状,直至出现声音嘶哑或呼吸困难,而声门下IMT罕见。基于我们病例的成功治疗,对于这种罕见肿瘤强烈推荐完整手术切除。然而,需要进一步研究以发现更有效且更具成本效益的治疗方法。