Department of Internal Medicine I, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
J Hepatol. 2022 Jul;77(1):237-242. doi: 10.1016/j.jhep.2022.05.001. Epub 2022 May 6.
At the beginning of April 2022, 10 cases of severe acute hepatitis of unknown origin in children <10 years of age were reported across central Scotland. Since then, case numbers have increased rapidly, with 191 probable cases identified across Europe, the United States of America, Israel and Japan. Until now, 17 children required liver transplantation and 1 died. Accordingly, the Centers for Disease Control and Prevention and the European Centre for Diseases Prevention and Control have both issued a warning on a hepatitis of unknown origin in children. This review focuses on the available information concerning this recent outbreak and introduces some of the potential explanations for its development.
2022 年 4 月初，苏格兰中部报告了 10 例 10 岁以下儿童不明原因的严重急性肝炎。此后，病例数量迅速增加，欧洲、美国、以色列和日本共发现 191 例疑似病例。到目前为止，已有 17 名儿童需要进行肝移植，其中 1 人死亡。因此，美国疾病控制与预防中心和欧洲疾病预防与控制中心均对儿童不明原因肝炎发出了警告。本综述重点介绍了关于此次暴发的现有信息，并提出了一些可能的发病原因。
