Grant R, Sutton D L, Behan P O, Ballantyne J P
J Neurol Neurosurg Psychiatry. 1987 Feb;50(2):199-206. doi: 10.1136/jnnp.50.2.199.
Abnormal calcium transport may be implicated in the membrane defect in myotonic dystrophy. A single blind crossover trial of placebo (t.i.d.), nifedipine 10 mg (t.i.d.) and nifedipine 20 mg (t.i.d.), was performed in 10 patients with myotonic dystrophy. The severity of myotonia was assessed by measuring finger extension time after maximum voluntary finger flexion. A significant improvement in myotonia, after nifedipine, was recorded by this technique and supported by a subjective improvement in 50% of patients and clinical improvement of greater than 20% in five patients. Initial grip strength and muscle fatiguability measured by grip strength ergometry were not significantly altered.
钙转运异常可能与强直性肌营养不良的膜缺陷有关。对10例强直性肌营养不良患者进行了一项单盲交叉试验，分别给予安慰剂（每日三次）、硝苯地平10毫克（每日三次）和硝苯地平20毫克（每日三次）。通过测量最大自主手指屈曲后手指伸展时间来评估肌强直的严重程度。用该技术记录到硝苯地平治疗后肌强直有显著改善，50%的患者主观感觉改善，5例患者临床改善超过20%。通过握力测力计测量的初始握力和肌肉疲劳性没有明显改变。
