Harlan W R, Harlan L C
J Hypertens Suppl. 1986 Dec;4(5):S334-9.
This review of epidemiological studies has several general implications. First, the most relevant population data for extrapolation in providing public health or medical advice should come from intra-population studies, either observational or interventional. Second, the observational studies require follow-up with long-term intervention trials in representative segments of the population before broad pronouncements are made. Third, not all people respond uniformly to changes in the intake of a single electrolyte, at the levels that can be safely achieved in our society. Finally, there are clear indications of useful directions in which to alter dietary electrolytes, either singly or multiply, but the most effective, safe and achievable combinations of dietary change remain to be defined and tested over prolonged periods in naturalistic settings.
这项流行病学研究综述具有若干普遍意义。首先，在提供公共卫生或医学建议时，用于外推的最相关人群数据应来自人群内部研究，无论是观察性研究还是干预性研究。其次，在做出广泛声明之前，观察性研究需要在具有代表性的人群中进行长期干预试验的随访。第三，并非所有人对单一电解质摄入量变化的反应都是一致的，即在我们社会中能够安全达到的水平上。最后，有明确迹象表明，单独或多种改变膳食电解质的有用方向，但膳食改变的最有效、安全和可实现的组合仍有待在自然环境中经过长时间定义和测试。
