Krishnan Sathish K, Mouleeswaran Karattupalayam S, Gopal Prasanna, Patcha Rajanikanth, Ramakrishna Somashekara H, Karnan Perumal, Malleeswaran Selvakumar, Varghese Joy, Reddy Mettu S
Department of Liver Transplant and Hepatopancreatico Biliary Surgery, Gleneagles Global Health City, Chennai, India.
Department of Pathology, Gleneagles Global Health City, Chennai, India.
J Clin Exp Hepatol. 2022 Mar-Apr;12(2):696-700. doi: 10.1016/j.jceh.2021.05.006. Epub 2021 May 28.
Liver tumours are uncommon in the paediatric population, constituting 1-2 % of all paediatric tumours and 4% of all paediatric liver tumours. Hepatoblastoma followed by hepatocellular carcinoma is the most common tumours in this age group. Simultaneous development of two discrete liver tumours of distinct histologies (collision tumour) has been occasionally reported in adults but never in children. We hereby present the first reported case of hepatic collision tumours (hepatocellular carcinoma and cholangiocarcinoma) in the explant liver of a child who underwent living donor liver transplantation for end-stage liver disease and severe hepatopulmonary syndrome. The manuscript describes the clinical, radiological and histopathological findings of this case and also highlights the dilemma associated with management of this case had the diagnosis been made in the preoperative setting and also about the proposed management plan for this case in the postoperative period.
肝肿瘤在儿科人群中并不常见，占所有儿科肿瘤的1%-2%，占所有儿科肝肿瘤的4%。在这个年龄组中，肝母细胞瘤其次是肝细胞癌是最常见的肿瘤。成人中偶尔有关于同时发生两种不同组织学类型的离散性肝肿瘤（碰撞瘤）的报道，但儿童中从未有过。我们在此报告首例儿童活体肝移植治疗终末期肝病和严重肝肺综合征的外植肝中发生肝碰撞瘤（肝细胞癌和胆管癌）的病例。本文描述了该病例的临床、放射学和组织病理学发现，并强调了如果术前做出诊断，该病例管理所面临的困境以及术后该病例的拟议管理计划。
