Tsegaye Nebiyu, Diriba Regasa, Araya Shambel
Addis Ababa University College of Health Science Department of Medical Laboratory Science, Addis Ababa, Ethiopia.
Int J Womens Health. 2022 May 2;14:635-642. doi: 10.2147/IJWH.S363137. eCollection 2022.
infections are associated with many complications of pregnancy including preeclampsia. It has been suggested that infection could contribute to the etiopathogenesis of preeclampsia by inducing a pro-inflammatory state.
To assess the magnitude of infection and its association with preeclamptic and non-preeclamptic pregnant women attending antenatal care in Ethiopia.
Hospital-based case control study was conducted among clinically diagnosed preeclamptic and non-preeclamptic pregnant women. Stool samples were collected for antigen test from study participants. The collected data were analyzed using statistical methods in SPSS version 23. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the study subjects. Association between clinical variables, preeclampsia and infection was performed with multivariate logistic regression. A p-value of <0.05 at 95% confidence level was considered as statistically significant in all the analyses.
A total of 93 cases and 186 controls were included in this study. The overall prevalence of infection in all study participants was 38.9% (16/272). The prevalence of infection was higher in cases than controls, 54.3% (50/92) vs 31.1% (56/180), respectively. The mean age was 29.01 (SD±4.93) years in cases and 30.37 (SD± 6.2) years in control group. A positive association was found between infection and preeclampsia (OR: 2.45; 95% CI: 2.41-4.10).
infection has been found to be associated with preeclamptic pregnant women. In this study, the prevalence of infection was higher in cases than in controls. Age group, educational status, occupational status and body mass index were significantly associated with preeclamptic women with . The association of with preeclampsia needs to be further explored.
感染与包括子痫前期在内的许多妊娠并发症相关。有人提出，感染可能通过诱导促炎状态而促成子痫前期的发病机制。
评估埃塞俄比亚产前护理中感染的程度及其与子痫前期和非子痫前期孕妇的关联。
在临床诊断为子痫前期和非子痫前期的孕妇中进行基于医院的病例对照研究。从研究参与者收集粪便样本进行抗原检测。使用SPSS 23版中的统计方法对收集的数据进行分析。简单描述性统计用于呈现研究对象的社会人口统计学和临床特征。临床变量、子痫前期和感染之间的关联通过多因素逻辑回归进行分析。在所有分析中，95%置信水平下p值<0.05被认为具有统计学意义。
本研究共纳入93例病例和186例对照。所有研究参与者中感染的总体患病率为38.9%（16/272）。病例组感染患病率高于对照组，分别为54.3%（50/92）和31.1%（56/180）。病例组平均年龄为29.01（标准差±4.93）岁，对照组为30.37（标准差±6.2）岁。发现感染与子痫前期之间存在正相关（比值比：2.45；95%置信区间：2.41 - 4.10）。
已发现感染与子痫前期孕妇有关。在本研究中，病例组感染患病率高于对照组。年龄组、教育程度、职业状况和体重指数与感染的子痫前期妇女显著相关。感染与子痫前期的关联需要进一步探索。
